A feasibility study of working memory training for individuals with paediatric-onset multiple sclerosis

ABSTRACT

Objective: To investigate the feasibility and experiences of paediatric-onset multiple sclerosis (MS) patients completing a working memory training programme.

Methods: Nine paediatric-onset MS patients (mean age 19.3 ± 4.1 years) identified as having attention and/or working memory difficulties underwent a five-week (five days/week) internet-based working memory training programme (Cogmed™); weekly coaching was provided. Measures of adherence and tolerance were used to establish the feasibility of implementing computerised cognitive training. Qualitative experiences reported by the patients were analysed and factors that may modulate the effects of training were explored.

Results: Six of the nine enrolled patients completed the programme within the recommended time, and all individuals, with the exception of one, were considered to tolerate the training well. Eight of the nine participants acknowledged that training was helpful in one or more ways. All but one participant reported improvements in working memory, although evidence for improvement on objective neuropsychological testing was limited. Lower normalised brain volume emerged as a potentially important variable in predicting extent of improvement on the training programme.

Conclusion: Selected paediatric-onset MS patients can tolerate and complete an intensive cognitive rehabilitation programme. Future investigation of moderators of training effects and the stability of the findings over time is needed.

KEYWORDS:

• Working memory training
• multiple sclerosis
• paediatric-onset
• cognitive rehabilitation
• feasibility

Acknowledgements

Cogmed™ and Cogmed Working Memory Training™ are trademarks, in the US and/or other countries, of Pearson Education, Inc. or its affiliate(s). Pearson Education did not play a role in the design or conduct of the study; analysis or interpretation of the data; or preparation or review of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Scottish Rite Charitable Foundation of Canada, a Minor Research Grant from York University, and a Doctoral award from the Multiple Sclerosis Society of Canada.