Multidimensional fatigue in Chinese patients with newly diagnosed meningiomas: Prevalence, severity and associated factors

ABSTRACT

Objective

The purpose of this study was to explore the prevalence, severity, and factors associated with multidimensional fatigue in Chinese patients with newly diagnosed meningiomas.

Methods

This cross-sectional study included 120 Chinese meningioma patients. Data were collected before surgery, including demographic, clinical, psychological, and sleep characteristics, as well as fatigue scores based on completion of the Multidimensional Fatigue Inventory (MFI-20). Mann–Whitney U tests, Kruskal–Wallis H tests, Spearman correlation and multiple linear regression were used to analyze the data.

Results

The results showed there was a high prevalence of severe fatigue for each dimension: general fatigue (33.3%), physical fatigue (27.5%), reduced activity (28.3%), reduced motivation (12.5%), mental fatigue (11.7%), and total fatigue (23.3%). Headache and anxiety were found to be associated with general fatigue. Depression was related with physical fatigue. The Karnofsky Performance Status (KPS) score and depression were associated with reduced activity. Depression and the Epworth Sleepiness Scale (ESS) score were correlated with reduced motivation, while the KPS score and anxiety were associated with mental fatigue. Importantly, comorbidity, the KPS score, headache, depression, sleep disturbances, and the ESS score remained strong correlates of total fatigue.

Conclusions

Our findings indicate that newly diagnosed meningioma patients are affected by multidimensional fatigue. For patients with risk factors of fatigue, targeted interventions are advised to decrease fatigue and improve HRQoL.

KEYWORDS:

• Meningioma
• fatigue
• quality of life
• multidimensional assessment

Acknowledgements

We would like to extend our sincere gratitude to our patients who were willing to participate in our study, share their experience with us, and help and support people around.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Authors’ contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by D. Zhang, Q. Wu, X. Gu, R. Li, and Z. Zong. The first draft of the manuscript was written by D. Zhang, X. Zhang, and Q Wu, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Data availability

The datasets generated during and/or analysed during the current study are not publicly available due to privacy concerns but are available from the corresponding author on reasonable request.

Declarations

Ethics approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the Affiliated Hospital of Nantong University (No. 2020-K042).

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Consent for publication

Not applicable

Code availability

Not applicable

Additional information

Funding

This work was supported by Science and technology Project of Nantong City (grant number MS12020011).