Preliminary evaluation of plasticizer and BPA in Tunisian cosmetics and investigation of hazards on human skin cells

Asma BeltifaResearch Unit of Analysis and Process Applied to Environmental –APAE UR17ES32 Higher Institute of Applied Sciences and Technology Mahdia, University of Monastir, Monastir, Tunisia;Faculté des Sciences Mathématiques, Physiques et Naturelles Université Tunis ElManar, Tunis, Tunisia

Afifa BelaidResearch Unit of Analysis and Process Applied to Environmental –APAE UR17ES32 Higher Institute of Applied Sciences and Technology Mahdia, University of Monastir, Monastir, Tunisia

Vincenzo Lo TurcoDipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali of the University of Messina, Messina, Italy

http://orcid.org/0000-0001-6633-6920

Monia MachrekiResearch Unit of Analysis and Process Applied to Environmental –APAE UR17ES32 Higher Institute of Applied Sciences and Technology Mahdia, University of Monastir, Monastir, Tunisia

Hedi Ben MansourResearch Unit of Analysis and Process Applied to Environmental –APAE UR17ES32 Higher Institute of Applied Sciences and Technology Mahdia, University of Monastir, Monastir, Tunisia

Giuseppa Di BellaDipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali of the University of Messina, Messina, ItalyCorrespondence[email protected]

http://orcid.org/0000-0001-8103-6942

ABSTRACT

In this study, 18 plasticizer (phthalates, adipates, sebacates, and others) and BPA residues in some cosmetic samples collected from Tunisian market are evaluated by micro-matrix solid-phase dispersion combined with GC-MS. In parallel, the impact of these molecules and the cosmetics in the human epithelial cell lines is investigated. The cytotoxic activity of cosmetic extracts is evaluated in vitro against B16 and Hep-2 human skin cell lines using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay.

This study shows that the tested cosmetic products could constitute a hazard to the consumer health and wellness and that strict safety analysis on cosmetic products needs to be carried out before they are marketed.

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Preliminary evaluation of plasticizer and BPA in Tunisian cosmetics and investigation of hazards on human skin cells

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