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Review Article

The effect of TiO2 nanoparticles on bacterial growth: the effect of particle size and their structure – a systematic review

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Pages 697-707 | Received 03 Nov 2022, Accepted 26 Dec 2022, Published online: 02 Jan 2023
 

ABSTRACT

One of the widely used microbiological methods to determine the toxicity of chemicals, catalysts, and other types of materials is the minimum inhibitory concentration (MIC) test. The present study aims to investigate the influence of composition of composite materials based on TiO2 and their particle size as well as bacterial type and shape based on the MIC values reported in the literature. The results show that among the 36 articles selected, most of the studies used Escherichia coli (E. coli) (26) and Staphylococcus aureus (S. aureus) (19) bacteria to determine MIC values. This study revealed that the MIC in values below 70 µg ml−1 for S. aureus was lower than that for E. coli bacteria (below 200 µg ml−1). Importantly, MIC value decreased from 60.6 to 7.66 µg ml−1 with decrease in the size of nanoparticles. It follows from the increased surface area for smaller-sized particles, thus increased interaction with bacteria during MIC test.

Highlights

  • Reported MIC values were lower for S. aureus than E. coli bacteria

  • More important nanoparticles structure than composition on the inhibiting properties

  • Direct relationship between the MIC value and particle size of TiO2 NPs

  • Considerable usage of rod-shaped bacteria than spherical shape for researchers

  • Importance of toxicity assessment of photocatalysts for water and wastewater treatment

Acknowledgements

The present study was adapted from the PhD thesis of Mehrdad Moslemzadeh at Iran University of Medical Sciences.

Disclosure statement

No potential conflict of interest was reported by the authors.

Availability of data and materials

All data generated or analyzed during this study are included in this published article.

Additional information

Funding

The present project was financially funded by grant number 98-4-2-16676 from Iran University of Medical Sciences.

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