In vitro antibiofilm, antibacterial, antioxidant, and antitumor activities of the brown alga Padina pavonica biomass extract

ABSTRACT

The antibiofilm, antibacterial, antioxidant, and anticancer activities of the methanolic extract of Padina pavonica L. were determined. Results deduced that the algal extract had a high biofilm formation inhibitory action done via crystal violet (CV) assay, to 88–99%. The results showed a strong antibacterial against the identified bacteria species. Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Klebsiella pneumonia, Bacillus subtilis, and the extract had moderate antibacterial activity against Escherichia coli, Pseudomonas fluorescens and Streptococcus agalactiae. The algal extract has a concentration-dependent DPPH radical scavenging activity (84.59%, with IC₅₀ = 170.31 µg/ml). The inhibitory percent of P. pavonica methanolic extract in vitro antiproliferative activity was 1.79–98.25% with IC₅₀ = 15.14 µg/ml against lung carcinoma. Phenols, terpenes, amino acids, alkaloids, flavones, alcohols, and fatty acids were among the metabolites whose biological actions were evaluated. In conclusion, for the first time, P. pavonica methanolic extract exhibited effective antibiofilm, antibacterial, antioxidant, and anticancer activities.      

KEYWORDS:

• Antibacterial
• antibiofilm
• padina pavonica
• methanolic extract
• lung cancer

Disclosure statement

No potential conflict of interest was reported by the authors.

Authors contribution

Mofida Makhlof and Abeer EL-Sayed carried out the experiments, constructed the figures and tables, and wrote the first draft of the manuscript. Mostafa El-Sheekh, shared the idea of the research, wrote, edited the manuscript, and revised the data and whole work.

Data availability statement

All data and materials are supplied in the manuscript

Additional information

Funding

The authors reported there is no funding associated with the work featured in this article.