Do dietary amino acid ratios predict risk of incident hypertension among adults?

Abstract

In the current study, we investigated the association between dietary amino acid ratios and the 3-year incidence of hypertension, conducted in the framework of the Tehran Lipid and Glucose Study with 4287 adults(41.9% men), aged 20–70 y. Dietary intakes of amino acids were assessed using a valid and reliable food frequency questionnaire and reported as percentage of protein. Then amino acid ratios including Leu.Ser/Thr.Trp, Leu/Trp, Leu/Thr, and Ser/Thr were calculated. We identified 429(10%) cases of hypertension during 3.1 y of follow up. The adjusted OR of the highest quartile of dietary Leu.Ser/Thr.Trp intake was 1.48 (95%CI:1.04–2.09, P for trend:0.02) compared with the lowest one. Furthermore, the OR of hypertension in the highest, compared with the lowest quartile of the leu/Thr ratio(2.19 vs 2.02) was 1.46(1.01–2.12), P for trend = 0.07. Our findings suggest that high dietary intakes of Leu.Ser/Thr.Trp ratio were associated with higher risk of incident hypertension and BP levels.

Keywords:

• Hypertension
• blood pressure
• leucine
• serine
• threonine
• tryptophan

Acknowledgements

We express our appreciation to the participants in the Tehran Lipid and Glucose Study for their enthusiastic support and to the staff of the Research Institute for Endocrine Sciences, Tehran Lipid and Glucose Study Unit for their valuable help. We also wish to acknowledge Ms Shiva for critical editing of the English grammar and syntax of the manuscript.

Disclosure statement

The authors report no conflict of interest.

Additional information

Funding

This work was supported by a grant from the National Institute for Medical Research Development (NIMAD) (Project No. 958296), Tehran, Iran.

Notes on contributors

Farshad Teymoori

F.T and G.A contributed in conception, design, statistical analysis. G.A, F.T, and H.F contributed in data collection and manuscript drafting. P.M and F.A supervised the study. All authors approved the final version of the manuscript.

Golaleh Asghari

F.T and G.A contributed in conception, design, statistical analysis. G.A, F.T, and H.F contributed in data collection and manuscript drafting. P.M and F.A supervised the study. All authors approved the final version of the manuscript.