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Studies in humans

Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial

Patricia Quezada-FernándezDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico; ;Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

Jhonatan Trujillo-QuirosDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico; ;Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

Sara Pascoe-GonzálezDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico; ;Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

Walter A. Trujillo-RangelDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico; ;Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

David Cardona-MüllerDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico; ;Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

Carlos G. Ramos-BecerraDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico; ;Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

Maricruz Barocio-PantojaDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico; ;Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

Mariana Rodríguez-de la CerdaDepartment of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

Esther Nérida Sánchez-RodríguezDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico;

Ernesto G. Cardona-MuñózDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico; ;Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

Leonel García-BenavidesDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico; ;Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico

Fernando Grover-PáezDepartment of Physiology, Pharmacology, Health Sciences University Center, University of Guadalajara, Guadalajara, Mexico; ;Department of Physiology, Arterial Stiffness Laboratory, Experimental Therapeutic and Clinic Institute, Health Sciences University Center, University of Guadalajara, Guadalajara, MexicoCorrespondence[email protected]

http://orcid.org/0000-0001-8203-3815

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Abstract

Type 2 diabetes mellitus (T2DM) is associated with premature atherosclerosis and arterial stiffening due to the accumulation of advanced glycation end-products in vessel walls. Green tea polyphenols are considered cardio-protective substances. In this randomised double-blind placebo-controlled trial (NCT02627898), we evaluated the effect of Green tea extract on arterial stiffness parameters, lipids, body composition and sRAGE levels. Twenty normotensive patients with T2DM treated with the standard therapy and statins, mean age 53.2 ± 9.4 years and mean BMI 30.1 ± 4.5 kg/m², were randomised to receive a daily dose of 400 mg of green tea extract (polyphenols ≥90%, EGCG ≥45%) or placebo for 12 weeks. Compared to placebo, administration of green tea extract decreased central augmentation index (–3.05 ± 10.8% vs. 6.7 ± 0.1%, p = .04). These findings suggest that green tea extract could be used as an adjunct to the standard therapy to improve arterial stiffness in T2DM.

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Acknowledgements

The authors would like to thank to the Arterial Stiffness Laboratory staff for their collaboration in compiling and analysing the data.

Disclosure statement

No potential conflict of interest was reported by the authors.

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Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial

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Effect of green tea extract on arterial stiffness, lipid profile and sRAGE in patients with type 2 diabetes mellitus: a randomised, double-blind, placebo-controlled trial

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