![Sample our Food Science & Technology journals, sign in here to start your access, latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5936/TOC-Subject-Sample-2021-Food-Science-Technology.jpg"})
Abstract
A controlled acute, cross-over clinical study (NCT02710461) was performed in order to evaluate the effects on glucose metabolism of a grape/pomegranate pomace dietary supplement in subjects with abdominal obesity (aged 40–60, n = 20). A standard 75 g oral glucose tolerance test (OGTT) was administered alone, together with or 10 h after the consumption of 10 g of the dietary supplement, rich in both extractable (0.4 g) and non-extractable (1.4 g) polyphenols. The dietary supplement did not ameliorate glucose or insulin at any sampling time. No improvement in antioxidant capacity was observed in plasma or urine, concordant with no increased urine polyphenol excretion. A tendency towards improved insulin sensitivity was observed when the product was consumed 10 h before glucose solution. These results suggest that a single realistic dose of grape/pomegranate pomace is not able to clearly improve glucose metabolism; chronic intake remains to be evaluated.
Acknowledgements
The authors are grateful to the Analysis Services Unit of ICTAN for microbiological, mineral, and chromatographic analyses. Dr. Laura Barrios, from the Subdirección General de Apoyo a la Investigación (SGAI) of the CSIC is also thanked for her assistance with statistical treatment. Vitalgrana S.A. and Roquesan Wineries are thanked for providing the raw materials of the dietary supplements. The authors are grateful to the volunteers for their participation in the study.
Disclosure statement
No potential conflict of interest was reported by the authors.