137
Views
0
CrossRef citations to date
0
Altmetric
Comprehensive reviews

Effects of betaine supplementation on inflammatory markers: a systematic review and meta-analysis of randomised controlled trials

, , , &
Pages 721-729 | Received 03 Jun 2023, Accepted 06 Sep 2023, Published online: 21 Sep 2023
 

Abstract

Several studies have suggested that betaine is closely related to inflammatory biomarkers that contribute to the development of metabolic diseases, but the effect remains controversial. This meta-analysis aimed to assess the effects of betaine supplementation on inflammatory markers based on randomised controlled trials (RCTs). PubMed, Web of Science and ResearchGate databases were searched up to March 2023. A total of 6 RCTs with 7 intervention trials involving 277 participants were included. Betaine supplementation led to a slight reduction in levels of circulating IL-1β of 0.65 pg/mL (95% CI, −1.23 to −0.06) with high heterogeneity (I2 = 95%). Betaine produced a small but nonsignificant reduction in levels of circulating CRP (0.33 mg/L; 95% CI, −1.79 to 1.14), IL-6 (0.47 pg/mL; 95% CI, −1.13 to 0.18) and TNF-α (0.25 pg/mL; 95% CI, −0.98 to 0.48). The present meta-analysis does not provide sufficient evidence to conclude that betaine supplementation improved the inflammation state.

Author contributions

JYX prepared the manuscript and interpreted the data; JYX, ZZN and XYQ performed the literature searches, data extraction and quality assessment; JYZ and SFH edited and reviewed the final manuscript, SFH designed this study, provided material support and supervised the study.

Disclosure statement

All the authors declare no conflict of interest.

Additional information

Funding

The present work was supported by grants from the Scientific Research Foundation for Scholars of HZNU (No. 2022QDL004).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.