![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Diacylglycerols are generated in the membrane as the result of extracellular signals and are able to stimulate the activity of protein kinase C, acting as membrane second messengers. Diacylglycerols are recognized by protein kinases C through the C1 domain and established models propose that they will stabilize the translocation of the protein to the membrane. However, diacylglycerols also act by modulating the physical properties of the membrane, thus favouring the translocation of the enzyme. This is done through alteration of the membrane surface curvature, dehydration of the surface and the separation of phospholipid surface groups. Good correlations have been observed between the physical state of the membrane and protein kinase C activity.
DAG, Diacylglycerols; DCG, dicaproyl-sn-glycerol; DEPE, 1,2-dielaidoyl-sn-glycero-3-phosphoethanolamine; DMG, dimyristoyl-sn-glycerol; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; DMPS, 1,2-dimyristoyl-sn-glycero-3-phospho-L-serine; DOG, dioleyl-sn-glycerol; DPG, dipalmitoyl-sn-glycerol; DPH, 1,6-diphenyl-1,3,5-hexatriene; dPPA, 12-deoxyphorbol 13-phenylacetate 20-acetate; DSC, differential scanning calorimetry; IP3, 1,4,5-inositol trisphosphate; N-methyl-DOPE, N-monomethyl-1,2-dioleyl-sn-phosphoethanolamine; NMR, nuclear magnetic resonance spectroscopy; PC, phosphatidylcholine; PDBu, phorbol 12,13-dibutyrate; PIP2, phosphatidylinositol 4,5-bisphosphate; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; POG, palmitoyl-oleyl-sn-glycerol; POPC; 1-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine; POPE, 1-palmitoyl-2-oleyl-sn-glycero-3-phosphoethanolamine; POPS, 1-palmitoyl-2-oleyl-sn-glycero-3-phospho-L-serine; PS, phosphatidylserine
DAG, Diacylglycerols; DCG, dicaproyl-sn-glycerol; DEPE, 1,2-dielaidoyl-sn-glycero-3-phosphoethanolamine; DMG, dimyristoyl-sn-glycerol; DMPC, 1,2-dimyristoyl-sn-glycero-3-phosphocholine; DMPS, 1,2-dimyristoyl-sn-glycero-3-phospho-L-serine; DOG, dioleyl-sn-glycerol; DPG, dipalmitoyl-sn-glycerol; DPH, 1,6-diphenyl-1,3,5-hexatriene; dPPA, 12-deoxyphorbol 13-phenylacetate 20-acetate; DSC, differential scanning calorimetry; IP3, 1,4,5-inositol trisphosphate; N-methyl-DOPE, N-monomethyl-1,2-dioleyl-sn-phosphoethanolamine; NMR, nuclear magnetic resonance spectroscopy; PC, phosphatidylcholine; PDBu, phorbol 12,13-dibutyrate; PIP2, phosphatidylinositol 4,5-bisphosphate; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; POG, palmitoyl-oleyl-sn-glycerol; POPC; 1-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine; POPE, 1-palmitoyl-2-oleyl-sn-glycero-3-phosphoethanolamine; POPS, 1-palmitoyl-2-oleyl-sn-glycero-3-phospho-L-serine; PS, phosphatidylserine