Clinical, Serological and Biochemical Studies on Lumpy Skin Disease

Abstract

Clinical signs of lumpy skin disease (LSD) were recorded. The period of fever was associated with serious biochemical alterations. Such alterations were obvious between 7th and 14th days from the initial symptoms. LSD infection in cattle produced transient changes in minerals and trace elements as well as malfunctional disturbances in both liver and kidneys. Moreover, the effects on the lymphoid tissue caused excessive production of immunoglobulins in the form of gamma-globulins. The changes in gamma-globulin also roughly paralelled the changes in serum neutralizing antibodies. Serum neutralizing antibodies developed on the second day from the onset of clinical signs and were detectable until the day 210. A significant rise in antibody titre was recorded between 21 and 42 days. This increase in antibody titre is important in diagnosis of LSD.

Key words:

• Lumpy Skin Disease
• Lymphadenitis
• Phagocytes