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Abstract
Sahoo, P.K, Chattopadhyay, S.K. and Sikdar A. 1995. Immunosuppressive effects of induced aflatoxicosis in rabbits. J. Appl. Anim. Res., 9: 17–26.
Graded levels of crude aflatoxin produced on chemically defined low salt medium with Aspergillus parasiticus NRRL 2999 were fed to young healthy New Zealand White rabbits. The toxin treated rabbits showed lymphopenia with compensatory neutrophillia. The results of DNCB contact sensitivity test for ascertaining cell mediated immunity (CMI) showed significant reduction in reactive skin diameter as well as less cellular and vascular reactions in skin biopsy sections. Reduced level of total serum protein concentration and heamagglutination (HA) titre against sheep erythrocytes (S.R.B.C.) revealed suppression of humoral immunity in toxin treated rabbits. The lymphoid follicles of caecum also showed depletion of lymphocytes which might be a contributory factor for immunosuppression. The results indicated that aflatoxin was a potential suppressor of both CMI and humoral immunity in rabbits.
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