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Abstract
El-Din, M.O.H., El-Sawi, N.M. and Meki, A.R.M.A. 1997. Acute toxicity of the mycotoxin roridin E on liver and kidney of rats. J. Appl. Anim. Res., 12: 145–152.
The effect of in vivo exposure to roridin E alone and in combination with linoleic add on rats was studied. Male rats treated with a sublethal dose (2 mg/kg body weight) of the trichothecene roridin E showed a significant increase in glucose-6-phosphatase of liver. Whereas, rats treated with roridin E plus linoleic acid (300 μmol/kg body weight) showed a significant decrease in the blood glucose and glutathione levels. The combined effect also resulted in a significant decrease in the levels of superoxide dismutase and glucose −6-phosphatase in the kidney together with a significant increase in the lipid peroxidation (TBARS) in the liver. In conclusion, treatment of rats by sublethal dose of roridin E alone did not caused any significant effect. However, co-administration of linoleic acid with roridin E resulted in increasing its toxicity.