Preliminary Trials on Development of Vaccine Against Mycoplasma mycoides subsp. mycoides type LC Infection in Goats

Abstract

Sunder, J., Srivastava, N.C. and Singh, V.P. 2002. Preliminary trials on development of vaccine against Mycoplasma mycoides subsp. mycoides type LC infection in goats. J. Appl. Anim. Res., 21: 75–80.

Studies were carried out on development of a killed vaccine against Mycoplasma mycoides subsp. mycoides type LC (MmmLC) infection in goats. Twenty five goats were immunized with 1 ml dose of the vaccine containing 2.5 mg protein of MmmLC with 3.0 mg sterile saponin through s/c route followed by a booster of the same dose and route at 4th week Pl. Group of these goats was challenged with virulent MmmLC (7.3x10⁹ cfu) by i/t route. The vaccine gave 80%, 80%, 71.5%, 75% and 75% protection at 21 days and, 3, 6, 9 and 12 months of challenge, respectively. Thus, it appears to be ready for testing on large scale before its release.

Key words:

• Mycoplasma
• vaccine
• immunity
• goats