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Abstract
El-Sawi, N.M. 2002. Effect of jelly fish crude venom on liver, thyroid and Harderian glands of female mice. J. Appl. Anim. Res., 22: 97–104.
To study the effect of jelly fish Eutonina indicans crude venom on liver, thyroid and Harderian glands, a sublethal dose was injected i.p. to female mice (1.78 mg/20g body weight). The concentration of porphyrin (μg/100mg) and the levels of serum thyroxine (T4), triiodothyronine (T3) and thyrotropic hormone (TSH) were determined. Histology of tissues from Harderian and thyroid gland were performed. The data indicate that the crude venom induced a highly significant increase (p>0.001) of porphyrin concentration, T3, T4 and TSH levels as compared with those of the control animal due probably to bradykinin which stimulates the synthesis or release of growth hormone or through the activation of prostaglandin synthesis and the thyroid hormones that act directly on Harderian gland. Also lipid peroxides (LPO), total thiols, glutathione, superoxide dismutase and catalase were assayed in liver homogenate and showed alterations of free radicals and antioxidants. The results suggest that this extract may be effective in elevation of T3 and T4 levels in the hypothyrodism patients.