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Abstract
Hosseini, S.V., Mehrabani, D., Tavakolian, A.R. and Tanideh, N. 2004. Role of an anti-inflammatory drug in prevention of intra-abdominal adhesions: An experimental study on guinea pigs. J. Appl. Anim. Res., 26: 123–125.
To study the effect of an anti-inflammatory drug (colchicin) on the induced adhesions in peritoneal cavity, adhesion bands were induced in 30 Short-Hair England guinea pigs by introducing talc-saline solution (10cc-10%). The animals were then randomly divided into two equal groups, the experimental and control. Colchicin was administered orally to the experimental group, whereas no drug was given to the control group. The animals were euthenized after 6 weeks and the adhesion bands in both groups were classified using the Nair classification and compared. Entire control group developed substantial adhesions, whereas, in experimental group only 26.7% developed substantial adhesions. Thus, 0.02 mg I kg colchicin could prevent I reduce the formation and severity of talc induced adhesion bands.