Changes of Heart Glycoconjugates by Noise Stress in Mouse as an Experimental Model

Abstract

Monsefi, M.Z. and Talaei, T. 2005. Changes of heart glycoconjugates by noise stress in mouse as an experimental model. J. Appl. Anim. Res., 27: 121–124.

To determine if glycoconjugates of a developing heart would change after noise exposure, forty-eight pregnant mice were exposed to the noise (100 dB) for 150 minutes per day from 2nd day of gestation to 7th day after birth. The new borns were sacrificed at deep anesthesia at the first, 7th and 14th days of their lives and their hearts were removed and stained with lectins (BSA₁-B₄, DBA, PNA and WGA). The mice with the same ages were also elected as control group. No histological changes were observed by light microscope, but some changes were noticed in the intensity of the reactions only to BSA₁-B₄ in endocardium, myocardium and pericardium of one and seven days old mice. This may be related to the increase in expression of galactose containing glycoconjugates when exposed to noise and these alterations in carbohydrates may lead to physiological malfunction during their life.

Keywords:

• Heart
• glycoconjugates
• lectin
• noise