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Abstract
Emami, M.J., Talebian, R. Tanideh, N. and Mehrabani, D. 2005. A Roentgenographs and biomechanical study on the effect of levothyroxine on fracture healing in rabbits. J. Appl. Anim. Res., 28: 113–116.
To determine the biomechanical and roentgenographic behaviour of the rabbit's tibial bone healing after levothyroxine administration, twenty-eight healthy Dutch rabbits (3 mo, 1200–1600 g) were used in a prospective, experimental, double blind, randomized control trial. Under general anesthesia, unilateral mid diaphyseal fracture of tibia was created through intact skin and was fixed with antegrade closed intramedullary nailing and casting. The rabbits were then divided into two equal groups. Levothyroxine (100 µg/kg b.wt./d) was administered orally to one group and placebo to other group of rabbits. Half the rabbits from both groups were sacrificed on d 21 and 31, respectively. Levothyroxine treatment improved mean mechanical bending force tolerance and roentgenographic grading 31 d post surgery but not at 21 d post surgery. Serum FT3 and FT4 levels were significantly increased by levothyroxine treatment on days 15, 21 and 31 post surgery. It is concluded that oral administration of levothyroxine for about 31 days would improve bending force tolerance and roentgenographic grading in the bone union of rabbits.