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Abstract
Hosseini, S.V., Motazedian, G.R., Mehrabani, D, Kumar, P.V, Bagheri, M.H, Tanideh, N, Yarmohammadi, H. and Sadjadi, S.M. 2006. Instillation of hypertonic glucose into gall bladder of rabbit: Does it induce sclerosing cholangitis? J. Appl. Anim. Res, 29: 73–76.
To study the effect of hypertonic glucose in induction of sclerosing cholangitis, glucose 10%, 15%, 25% and 50% were injected transhepatically into the gall bladder of 4 equal groups of 12 Dutch rabbits. Normal saline was similarly injected as group 5 (control group). Porta-hepatis was clamped for 5 minutes. Macroscopically and microscopically, the livers were normal without any bile stasis, fibrosis or nodular formation after 5 months of glucose injection. There was no sign of sclerosing cholangitis or cirrhosis. It is concluded that hypertonic glucose developed no sclerosing cholangitis or hepatic damage and is a safe scolicidal agent.