Histochemical Studies on Structural Changes of Large Conducting Arteries in Male Diabetic Rats

Abstract

Arab, M.R., Komeili, G.R., Touhidi, A., Sargolzaie, A.F. and Shahraki, M.R. 2006. Histochemical studies on structural changes of large conducting arteries in male diabetic rats. J. Appl. Anim. Res., 30: 145–148.

To examine the structural and histochemical changes of aorta and common carotid arteries in male diabetic rats, 63 male Sprague Dawley rats were randomly divided into experimental (n=36) and control (n=27) groups. Diabetes was induced by intraperitoneal injection of 60 mg/kg of streptozotocin in experimental group. There was a significant difference only for periodic acid schiffpositive material in subintimal connective tissue between control and 4 months diabetic groups (P<0.007). Peanut agglutinin staining showed the presence of Galactose IN-Acetyl galactosamine in glycoconjugates of sub-endothelial and adventitial components of studied arteries. It seems that in diabetes, the rate of glycosylation of cell surface and extracellular matrix glycoconjugates changed slowly.

Key words:

• Aorta
• carotid
• diabetes mellitus
• lectin
• rat