Effect of Nigella sativa L. Oil on Roridin E Toxin Administration on Liver of Male Mice

Abstract

Qusti, S.Y. and El-Sawi, N.M. 2007. Effect of Nigella sativa L. oil on roridin E toxin administration on liver of male mice. J. Appl. Anim. Res., 31: 161–164

To study the effect of Nigella sativa L Oil (N.S.) on mice given roridin E toxin, 30 albino mice were divided in 3 equal groups. Control group mice were given only the carrier of roridin E. Second group mice were given roridin E (2 mg/kg bw). Third group mice were given toxin as in group 2 but were given 800mg/kg bw of NS oil additionally. Liver tissue and blood serum analysis indicated that lipid peroxidation parameters were increased by toxin but NS oil brought these to normal level. Thus NS oil as antidote to rordin E toxicity is demonstrated.

Keywords:

• Mycotoxin
• roridin E
• Nigella sativa L. oil
• trichothecene
• antioxidants
• serum
• liver