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Abstract
The objective of the study was to evaluate the effect of aqueous extract of stem bark of Mangifera indica (M. indica) on gentamicin (GM)-induced nephrotoxicity. A total of 32 male Sprague–Dawley rats were divided in four equal groups. Group 1 was kept as normal healthy control and Group 2 was maintained as GM control in which the animals were intraperitoneally administered GM at 80 mg/kg for 8 days. Groups 3 and 4 were administered with M. indica at 100 mg/kg b.w. and 500 mg/kg b.w., respectively from day 9 to day 30. Nephrotoxicity was evaluated by an increase in the serum creatinine, urea and lipid peroxidation and a decrease in the superoxide dismutase (SOD), catalase (CT) and reduced glutathione (RG) levels. The aqueous extract of stem bark of M. indica at 100 mg/kg and 500 mg/kg reduced (P<0.05) serum creatinine, urea and lipid peroxidation and increased (P<0.05) SOD, CT and RG levels in a dose dependent manner. It reduced the GM-induced changes of serum Na and K upto 15 days. However, the histopathological examination revealed that the aqueous extract of stem bark of M. indica could not provide a complete therapeutic effect in GM-induced nephrotoxicity as evidenced by subcapsular tubular necrosis, dilatation of distal convoluted tubules and hyaline cast formation in the treated groups. To conclude, the results of the present study indicated that the aqueous extract of stem bark of M. indica prevented the GM-induced free radical formation.
Acknowledgements
The authors are thankful to Dr. K.T. Prasanna Kumari for authenticating the plant material. The financial support provided by Kerala Agricultural University is duly acknowledged. The authors are also grateful to the Dean, Faculty of Veterinary and Animal Sciences for providing the facilities for conducting the studies.