Repair of abdominal wall hernias using acellular dermal matrix in goats

Abstract

The present study was undertaken to evaluate the efficacy of acellular dermal matrix (ADM) of caprine origin for the repair of abdominal wall hernias in six goats. The skin of goat was de-epithelialised using a 2 M sodium chloride solution and 0.25% trypsin, and further decellularised using 2% sodium deoxycholate, which was then used as graft material. Under xylazine sedation and local infiltration analgesia, the abdominal wall hernias were repaired with ADM graft using inlay graft technique. All animals had an uneventful recovery without clinical signs of wound dehiscence, infection or recurrence of hernia during 6 months follow-up periods.

Keywords:

• acellular dermal matrix
• abdominal wall hernias
• inlay graft technique
• goats

Acknowledgements

The authors acknowledge the financial assistance received from the Department of Biotechnology, Ministry of Science and Technology, New Delhi, India to carry out this research work.