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Abstract
The chemical composition of essential oils obtained from two parts of Piper magnibaccum C.DC. were analyzed by gas chromatography with a flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). 25 components representing 93.5% of the essential oil were characterized from the leaf of P. magnibaccum. The essential oil was dominated by germacrene D (40.8%), β-caryophyllene (8.5%) and α-cadinol (6.1%). A total of 33 components, representing 87.6% of the total oil were identified from the stem of P. magnibaccum. The major constituents were β-caryophyllene (19.7%), germacrene D (10.7%), and α- cadinol (8.2%). The antioxidant potential of the leaf and stem essential oils of P. magnibaccum were determined on the basis of phenolic content and scavenging activity of the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) (IC50 20.5, 17.5 μg/mL) and 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS) (IC50 11.7, 12.9 μg/ mL) free radicals. Antityrosinase activity of the leaf and stem were also screened using mushroom tyrosinase assay (I %= 49.50±0.6, 57.01±0.8). The essential oil of P. magnibaccum leaf showed a moderate antibacterial activity with MIC value of 250 μg/mL against P. aeruginosa. None of the essential oils exhibited acute cytotoxicity against MCF-7 and A-549 cells proliferation.