ABSTRACT
Complexation of biologically active water-soluble flexible chain microassembled N-vinylpyrrolidone–N-vinylamine copolymers with ions was studied by complex chromatographic techniques (high-performance liquid chromatography and thin-layer chromatography). Constants of complex formation were evaluated (Kb = 4.6 × 105). Hydrodynamic behavior and molecular radii of the prepared metal-polymeric compounds were evaluated by molecular optics and hydrodynamic methods [viscosimetry, sedimentation diffusion analysis, dynamic light scattering, and flow birefringence (Maxwell effect)]. No significant changes in hydrodynamic properties of metal-polymeric complexes as compared with those of the pure copolymers were observed. Thus, the suggested approach seems to be promising for producing noninvasive metal-polymeric complexes for biological purposes.