3D scaffolds prepared from acylated chitosan applicable in skin regeneration – synthesis and characterization

Abstract

Nowadays, burn wounds are one of the most emerging problems of medicine. Tissue engineering seems to be a promising solution since it enables new tissue formation on 3 D scaffolds. In this article, a novel strategy for N-acylated chitosan 3 D scaffolds obtainment method is presented. Biomaterials were synthesized according to Green Chemistry principles under microwave-assisted conditions using unsaturated fatty acid chlorides. Ready products were characterized over their physicochemical properties, morphology, mechanical, and biological properties. Performed analyses confirmed obtainment of N-acylated biomaterial with a very porous structure and enhanced durability. Prepared scaffolds were biodegradable and had a positive impact on mouse fibroblasts.

Keywords:

• Chitosan
• biodegradable polymers
• biomaterials
• 3D scaffolds
• microwave radiation
• Green Chemistry