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Abstract
Hematopoietic stem cell transplantation has been available as a therapeutic modality for selected adult patients in Vancouver, British Columbia since 1981. We report on the history, progress, and future prospects of the Leukemia/Bone Marrow Transplantation Program of British Columbia. The basic mechanisms and indications for hematopoietic stem cell transplantation are outlined. Limitations of this procedure are also examined, particularly that of associated toxicities such as graft-versus-host-disease.