μ-Heavy Chain Disease Associated with Systemic Amyloidosis

Abstract

μ-heavy chain disease (HCD) is very rare, with only 30 cases reported in the literature. We report a patient with μ-HCD associated with systemic amyloidosis. The diagnosis of μ-HCD was based on findings of μ-heavy chain fragments in the serum, Bence Jones proteinuria and vacuolated plasma cells in the bone marrow. To our knowledge, this is the third case in which systemic amyloidosis led to the patient's death.

Keywords:

• μ-HCD
• AL amyloidosis
• Bence Jones proteinuria
• Vacuolated plasma cell