Nephrotic Syndrome Associated with Chronic Lymphocytic Leukaemia

Abstract

The simultaneous presentation of B-cell chronic lymphocytic leukaemia and nephrotic syndrome is described. The leukaemia responded to cytotoxic therapy but prednisolone was required to achieve remission of the nephrotic syndrome. The nephrotic syndrome relapsed when the leukaemia again became active and the white cell count rose above 20 × 10 9 /l, and it remitted again with treatment. The relationship between the two diseases is discussed.

Keywords:

• Chronic lymphocytic leukaemia
• Nephrotic syndrome
• Chlorambucil
• Proteinuria
• Cyclophosphamide