Update on the Treatment of Disseminated Intravascular Coagulation

Abstract

Disseminated intravascular coagulation (DIC) is characterized by an acute generalized, widespread activation of coagulation, which results in thrombotic complications, due to the intravascular formation of fibrin, as well as diffuse hemorrhages, due to the consumption of platelets and coagulation factors. In this review, we briefly report the present knowledge about the treatment of DIC. We focus on the current standard treatment of overt DIC in clinical practice. Moreover, particular attention is made to novel therapeutic strategies, who reflect the important progresses in the understanding of the pathogenesis of this syndrome in the last few years.

Keywords:

• Disseminated intravascular coagulation
• Replacement therapy
• Anticoagulation
• AT-III
• Protein C
• Fibrinolytic inhibitors