t(8;16) AML developed subsequent to breast cancer therapy

Feride Iffet SahinDepartment of Medical GeneticsBaskent University Faculty of Medicine, Ankara, Turkey

Zerrin YilmazDepartment of Medical GeneticsBaskent University Faculty of Medicine, Ankara, Turkey

Sema KarakuşDepartment of Adult HematologyBaskent University Faculty of Medicine, Ankara, Turkey

Salih BoĝaDepartment of Adult HematologyBaskent University Faculty of Medicine, Ankara, Turkey

Zefer AkçaliDepartment of Medical OncologyBaskent University Faculty of Medicine, Ankara, Turkey

Beyhan DemirhanDepartment of PathologyBaskent University Faculty of Medicine, Ankara, Turkey

Abstract

We report a breast cancer patient who developed acute myeloid leukemia (AML) one year following her adjuvant chemotherapy consisting of cyclophosphamide, adriamycin and 5-fluorouracil. Cytogenetic examination of bone marrow samples resulted in t(8;16)(p11.2;p13.3), which is a chromosome rearrangement observed in de novo and treatment related AML M4/M5 with a poor prognosis.

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t(8;16) AML developed subsequent to breast cancer therapy

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t(8;16) AML developed subsequent to breast cancer therapy

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