Umbilical cord blood transplantation using non-myeloablative conditioning: The Mexican experience

Abstract

Twenty-eight children and adults underwent transplantation with allogeneic umbilical cord blood cells (UCB) using a non-ablative conditioning regimen; there were 15 males and 13 females. Seven patients were grafted because a non-malignant condition and 21 for a malignant disease. The median age was 8 years (range 4 months–72 years). Ten UCB were obtained from Mexican cord bloods banks, five cords were from compatible siblings and the remaining 13 cords were obtained from abroad. Median time to recover > 0.5 × 10₉/1 granulocytes was 24 days (range 8–32 days), whereas median time to recover > 20 × 10₉/1 platelets was 26 days (range 12–50 days). Twelve recipients never engrafted and recovered subsequently endogenous hematopoiesis. The non-engraftment rate was significantly higher in patients allografted for benign conditions (71 %) than in those allografted for malignant conditions (28%). The median overall post-transplant survival (SV) was 33 months and the 73-months overall SV was 39%. The cumulative incidence of grade II–IV acute GVHD and grade III–IV GVHD for the entire cohort of patients were 14 and 7%, respectively. Additional studies are needed to define if non-myeloablative conditioning is preferable over conventional conditioning in the case of UCB allografting.

Keywords:

• UMBILICAL CORD BLOOD
• TRANSPLANTATION
• NON-MYELOABALATIVE CONDITIONING
• HEMATOPOIESIS