Pathogenesis of Autoimmune Diseases in Large Granular Lymphocyte Leukemia

Thierry LamyH. Lee Moffitt Cancer Center and Research Institute, the Veterans's Administration Hospital, and the Departments of Medicine, and Microbiology/Immunology, University of South Florida Medical School, Tampa, Florida

Thomas P. Loughran Jr.H. Lee Moffitt Cancer Center and Research Institute, the Veterans's Administration Hospital, and the Departments of Medicine, and Microbiology/Immunology, University of South Florida Medical School, Tampa, FloridaCorrespondence[email protected]

Abstract

Large granular lymphocyte (LGL) leukemia is often associated with autoimmune diseases. The clinical associations of autoimmune diseases occurring in LGL leukemia are reviewed. Current concepts regarding the pathogenesis of LGL leukemia are summarized. It is suggested that LGL leukemia can serve as a useful model of dysregulated apoptosis as an underlying mechanism for both malignancy and autoimmune disease.

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Pathogenesis of Autoimmune Diseases in Large Granular Lymphocyte Leukemia

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Pathogenesis of Autoimmune Diseases in Large Granular Lymphocyte Leukemia

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