Animal models of social stress: the dark side of social interactions

Abstract

Social stress occurs in all social species, including humans, and shape both mental health and future interactions with conspecifics. Animal models of social stress are used to unravel the precise role of the main stress system – the HPA axis – on the one hand, and the social behavior network on the other, as these are intricately interwoven. The present review aims to summarize the insights gained from three highly useful and clinically relevant animal models of psychosocial stress: the resident-intruder (RI) test, the chronic subordinate colony housing (CSC), and the social fear conditioning (SFC). Each model brings its own focus: the role of the HPA axis in shaping acute social confrontations (RI test), the physiological and behavioral impairments resulting from chronic exposure to negative social experiences (CSC), and the neurobiology underlying social fear and its effects on future social interactions (SFC). Moreover, these models are discussed with special attention to the HPA axis and the neuropeptides vasopressin and oxytocin, which are important messengers in the stress system, in emotion regulation, as well as in the social behavior network. It appears that both nonapeptides balance the relative strength of the stress response, and simultaneously predispose the animal to positive or negative social interactions.

Keywords:

• Social stress
• aggression
• chronic subordinate colony housing
• social fear
• oxytocin
• vasopressin

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by Deutscher Akademischer Austauschdienst (DAAD) and Universidad de Costa Rica under the Grant ALECOSTA-57176158 (M.M.), Deutsche Forschungsgemeinschaft GRK 2174 (A.B., M.R., I.D.N.), DFG (Ne 31/1), EU (7th Framework, FemNAT; V.O., T.d.J., I.D.N.), and BMBF (OptiMD; A.S., I.D.N.).