Protective action of alkylglycerols under stress

Abstract

The adaptogenic properties of alkylglycerols (AGs) after 1 month’s treatment were investigated in a rat model of acute immobilization stress (AIS). The animals receiving AGs 157 mg/kg showed a body weight (BW) decrease in addition to a more pronounced increase in the adrenal glands index under stress conditions. Also, AGs at this dose prevented AIS-induced catalase inhibition. In addition, antiulcerative AG effects were already detected at a dose of 15 mg/kg. The data indicate that AGs promote adrenal gland activation in AIS. At the same time, AGs neutralize some of negative effects of stressful conditions, which include restoration of the oxidation–reduction balance, reduction of gastric mucosal stress lesion formation.

LAY SUMMARY

• The effect of alkylglycerols, ether lipids from marine organisms, was studied in stressed animals. AGs have antioxidant activity and can be useful in the complex therapy of stomach lesions.

Keywords:

• Acute immobilization stress
• ether lipids
• chimyl alcohol
• batyl alcohol
• alkylglycerols
• adaptogenic action
• marine organisms

Acknowledgements

The authors thank I. A. Barsegova for help in preparing this manuscript for publication, Yu. K. Denisenko for his assistance in the biochemical analysis, E. I. Drobot and V. V. Chaika for participation in the morphological studies.

Disclosure statement

The authors declare that there is no conflict of interest.

Note on Contributions

Poleschuk T. S.: setting up an experiment and medical research; Sultanov R. M.: preparation of AGs; Ermolenko E. V.: gas-chromatography and mass-spectrometry analysis of AGs; Shulgina L. V.: medical research; Kasyanov S. P.: conceptualization of the experiment.

Additional information

Funding

Histological studies were supported by the Russian Science Foundation [Project no. 14-50-00034].