Fos Expression in CRF-containing Neurons in the Rat Paraventricular Nucleus after Central Administration of Neuromedin U

Makoto Yokota Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan

Yumi Ozaki Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan

Fumihiko Sakamoto Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan

Seiji Yamada Department of Occupational Health, Matsushita Science Center of Industrial Hygiene, 7-6 Tonoshima-cho, Kadoma, 571-0045, Japan

Jun Saito Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan

Hiroaki Fujihara Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, Japan

Yoichi Ueta Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, 807-8555, JapanCorrespondence[email protected]

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Abstract

We examined the effects of centrally administered neuromedin U (NMU) on corticotrophin-releasing factor (CRF)-containing neurons in the hypothalamic paraventricular nucleus (PVN) of rats, using double immunohistochemistry for CRF and Fos. Almost all CRF-containing neurons in the parvocellular divisions of the PVN expressed Fos-like immunoreactivity 90 min after intracerebroventricular administration of NMU (3 nmol/rat). This results suggest the possibility that central NMU may be involved in stress-induced activation of CRF-containing neurons in the PVN.

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Fos Expression in CRF-containing Neurons in the Rat Paraventricular Nucleus after Central Administration of Neuromedin U

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Fos Expression in CRF-containing Neurons in the Rat Paraventricular Nucleus after Central Administration of Neuromedin U

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