Certain Trace Metal Disorders in Urinary Bladder of Bilharzial Patients suffering Bladder Carcinoma

Abstract

The objective of the present work is to investigate any possible role which could have been played by the long-term treatment with antimony as an antibilharzial drug, and the development of urinary bladder carcinoma in patients suffering bilharzial complications. The present work has been planned to investigate the concentration levels of copper, zinc and antimony in urinary bladder tissues sampled from normal, bilharzial and bladder cancer patients subjected to surgical intervention. Both atomic absorption spectrophotometry and neutron activation analysis have been utilized for elemental estimations. The data obtained showed significant increase in the concentration levels of the three investigated metals in bladder cancer tumours as compared with their control levels under either normal or cancer-free bilharzial complications. The results have been statistically evaluated and discussed in view of the relevant literature. It has been concluded that the contributing role of the antibilharzial antimonial treatment in development of urinary bladder cancer cases cannot be overlooked and awaits further investigation.

Keywords:

• absorption spectroscopy
• antimoy
• bladder
• carcinoms
• chemical analysis
• copper
• drugs, neoplasms
• neutron activation analysis
• nondestructive analysis
• patients
• quantity ralis
• therapy
• tumor promoters
• zinc