Abstract
335 [15N2]urea examinations to detect gastric Helicobacter pylori infection were performed using a uniform study protocol broadened to obtain a large quantity of various experimental data. The data were compiled and assessed in order to establish the most suitable parameter for a standardized test protocol. Second-hour urine following oral administration of the diagnostic agent was found to produce the clearest distinction between H. pylori-infected and non-infected persons. The threshold value of c = 0.06 (the quotient of 15Nexcess abundance in urinary ammonia and 15Nexcess abundance in the urinary urea) is not age-dependent Though less suitable on its own, the 15Nexcess abundance of urinary ammonia is useful as a second parameter for interpreting the results in the case of c values slightly below 0.06. The standardized test protocol is specified.
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