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Nutritional Neuroscience
An International Journal on Nutrition, Diet and Nervous System
Volume 9, 2006 - Issue 1-2
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Articles

Role of lifestyle factors on plasma homocysteine levels in Parkison's disease patients treated with levodopa

Antonio Siniscalchi“Annunziata” Hospital Neurology Division, Department of Neuroscience, Cosenza, Italy
,
Luca GallelliMater Domini University Hospital Clinical Pharmacology Unit, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery University “Magna Grecia”, Catanzaro, Italy
,
Nicola B. MercuriUniversity “Tor Vergata” IRCCS S. Lucia and Department of Neurology, Rome, Italy
,
Guido Ferreri IbbaduMater Domini University Hospital Clinical Pharmacology Unit, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery University “Magna Grecia”, Catanzaro, Italy
&
Giovambattista De SarroMater Domini University Hospital Clinical Pharmacology Unit, Department of Experimental and Clinical Medicine, Faculty of Medicine and Surgery University “Magna Grecia”, Catanzaro, Italy
Pages 11-16 | Published online: 05 Sep 2013
 
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Abstract

Many papers documented that Parkinson's disease (PD) patients treated with levodopa (l-dopa) shows elevated plasma homocysteine (Hcy) levels. Several lifestyle factors are able to influence plasma Hcy levels. We review the evidence that l-dopa therapy is related with an increase in plasma Hcy levels and that several behaviours could be able to cause changes in plasma Hcy concentrations. Therefore, there are reasons to suggest that a healthy lifestyle lowering Hcy may prevent this potential iatrogenic complication during l-dopa therapy. Moreover, at present, no controlled prospective studies have evaluated this phenomenon.

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Related Research Data

Benefit of folic acid supplementation in parkinsonian patients treated with levodopa.
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