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Abstract
Primary objectives: Body composition and obesity-related lifestyle factors are associated with increased risk for Alzheimer's disease (AD). Amyloid beta (Aβ) is a peptide integral in the pathogenesis of AD. Aβ has been shown to be related to body fat and exercise in younger adults; however, no study to date has examined the possible relationship among Aβ, body composition and fitness indices in older adults.
Methods and procedures: Thirty-five older adults without significant neurological or psychiatric history, underwent fasting blood draw and completed cognitive testing and body composition and physical fitness assessments.
Results: Partial correlations showed Aβ levels were inversely related to cognitive function, body fat and physical fitness measures.
Conclusions: Findings indicate Aβ is associated with cognitive function, body fat and physical fitness in neurologically healthy older adults. Further work is needed to clarify possible mechanisms, particularly longitudinal studies.