https://orcid.org/0000-0003-4326-3102
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ABSTRACT
Objectives: Inbred mouse strains differ in the pharmacology mediating sugar and fat intake and conditioned flavor preferences (CFP). C57BL/6, BALB/c and SWR inbred mice are differentially sensitive to dopamine (DA) D1, opioid and muscarinic receptor antagonism of sucrose, saccharin or fat intake, and to DA, opioid, muscarinic and N-methyl-D-aspartate (NMDA) receptor antagonism of acquisition of sucrose-CFP. DA D1, opioid and NMDA receptor antagonists differentially alter fat (Intralipid)-CFP in BALB/c and SWR mice. The present study examined whether naltrexone, SCH23390 or MK-801 altered acquisition and expression of Intralipid-CFP in C57BL/6 mice.
Methods: In acquisition, groups of male food-restricted C57BL/6 mice received vehicle, naltrexone (1, 5 mg/kg), SCH23390 (50, 200 nmol/kg) or MK-801 (100, 200 μg/kg) before 10 training sessions in which mice alternately consumed two novel-flavored 5% (CS+) and 0.5% (CS-) Intralipid solutions. Six two-bottle CS choice tests followed with both flavors mixed in 0.5% Intralipid without injections. In expression, C57BL/6 mice underwent the 10 training sessions without injections followed by two-bottle CS choice tests 30 min following vehicle, naltrexone (1, 5 mg/kg), SCH23390 (200, 800 nmol/kg) or MK-801 (100, 200 μg/kg).
Results: Fat-CFP acquisition in C57BL/6 mice was significantly though marginally reduced following naltrexone, SCH23390 and MK-801. Fat-CFP expression was similarly reduced by naltrexone, SCH23390 and MK-801 in C57BL/6 mice. Discussion: C57BL/6 mice were more sensitive to DA D1, opioid and NMDA antagonists in the expression of fat-CFP relative to sugar-CFP, but were less sensitive to DA D1 and NMDA antagonists in the acquisition of fat-CFP relative to sugar-CFP.
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Notes on contributors
Julia Iskhakova
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov and David Fazylov were all undergraduate researchers in Dr. Bodnar's laboratory at Queens College, CUNY. Dr. Richard Bodnar is a Professor of Psychology at Queens College, CUNY, and the Executive Officer of the Psychology Doctoral Program at the Graduate Center of CUNY.
Tatjana Mustac
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov and David Fazylov were all undergraduate researchers in Dr. Bodnar's laboratory at Queens College, CUNY. Dr. Richard Bodnar is a Professor of Psychology at Queens College, CUNY, and the Executive Officer of the Psychology Doctoral Program at the Graduate Center of CUNY.
Asnat Yuabov
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov and David Fazylov were all undergraduate researchers in Dr. Bodnar's laboratory at Queens College, CUNY. Dr. Richard Bodnar is a Professor of Psychology at Queens College, CUNY, and the Executive Officer of the Psychology Doctoral Program at the Graduate Center of CUNY.
Jason Macanian
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov and David Fazylov were all undergraduate researchers in Dr. Bodnar's laboratory at Queens College, CUNY. Dr. Richard Bodnar is a Professor of Psychology at Queens College, CUNY, and the Executive Officer of the Psychology Doctoral Program at the Graduate Center of CUNY.
Emanuel Israel
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov and David Fazylov were all undergraduate researchers in Dr. Bodnar's laboratory at Queens College, CUNY. Dr. Richard Bodnar is a Professor of Psychology at Queens College, CUNY, and the Executive Officer of the Psychology Doctoral Program at the Graduate Center of CUNY.
Petra Dohnalova
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov and David Fazylov were all undergraduate researchers in Dr. Bodnar's laboratory at Queens College, CUNY. Dr. Richard Bodnar is a Professor of Psychology at Queens College, CUNY, and the Executive Officer of the Psychology Doctoral Program at the Graduate Center of CUNY.
Ben Iskhakov
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov and David Fazylov were all undergraduate researchers in Dr. Bodnar's laboratory at Queens College, CUNY. Dr. Richard Bodnar is a Professor of Psychology at Queens College, CUNY, and the Executive Officer of the Psychology Doctoral Program at the Graduate Center of CUNY.
Eden Ben Lulu
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov and David Fazylov were all undergraduate researchers in Dr. Bodnar's laboratory at Queens College, CUNY. Dr. Richard Bodnar is a Professor of Psychology at Queens College, CUNY, and the Executive Officer of the Psychology Doctoral Program at the Graduate Center of CUNY.
Sonya Aminov
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov and David Fazylov were all undergraduate researchers in Dr. Bodnar's laboratory at Queens College, CUNY. Dr. Richard Bodnar is a Professor of Psychology at Queens College, CUNY, and the Executive Officer of the Psychology Doctoral Program at the Graduate Center of CUNY.
David Fazylov
Julia Iskhakova, Tatjana Mustac, Asnat Yuabov, Jason Macanian, Emanuel Israel, Petra Dohnalova, Ben Iskhakov, Eden Ben Lulu, Sonya Aminov and David Fazylov were all undergraduate researchers in Dr. Bodnar's laboratory at Queens College, CUNY. Dr. Richard Bodnar is a Professor of Psychology at Queens College, CUNY, and the Executive Officer of the Psychology Doctoral Program at the Graduate Center of CUNY.