Meat consumption, depressive symptomatology and cardiovascular disease incidence in apparently healthy men and women: highlights from the ATTICA cohort study (2002–2012)

ABSTRACT

Objectives: To evaluate the association of meat consumption with prevalent depressive symptomatology and cardiovascular disease (CVD) incidence in apparently healthy individuals.

Methods: ATTICA study was conducted during 2001–2012 including n = 1514 men and n = 1528 women (aged >18 years old) from the greater Athens area, Greece. At baseline, depressive symptomatology through Zung Self-Rating Depression Scale (range 20–80) and meat consumption (total meat, red, white and processed meat) through validated semi-quantitative food frequency questionnaire were assessed. Follow-up (2011–2012) was achieved in n = 2020 participants (n = 317 cases); n = 845 participants with complete psychological metrics were used for the primary analysis.

Results: Ranking from 1st to 3^rd total meat consumption (low to high) tertiles, participants assigned in 2^nd tertile had the lowest depressive-symptomatology scoring (p<0.001). This trend was retained in multiadjusted logistic regression analysis; participants reporting moderate total and red meat consumption had ∼20% lower likelihood to be depressed (i.e. Zung scale<45) compared with their 1st tertile counterparts (Odds Ratio (OR)_{total meat} 0.82, 95% Confidence Interval (95%CI) (0.60, 0.97) and OR_{red meat} 0.79 95%CI (0.45, 0.96)). Non-linear associations were revealed; 2–3 serving/week total meat and 1–2 servings/week red meat presented the lowest odds of depressive symptomatology (all ps<0.05). These U-shape trends seemed to attenuate the aggravating effect of depressive symptomatology on CVD hard endpoints. All aforementioned associations were more evident in women (all ps for sex-related interaction<0.05).

Discussion: The present findings generate the hypothesis that moderate total meat consumption and notably, red meat may be more beneficial to prevent depressed mood and in turn hard CVD endpoints.

KEYWORDS:

• Meat
• red meat
• psychological health
• depression
• heart disease
• gender
• women
• primary prevention

Acknowledgements

The authors would like to thank the ATTICA study investigators: Y. Skoumas, N. Katinioti, L. Papadimitriou, C. Masoura, S. Vellas, Y. Lentzas, M. Kambaxis, K. Paliou, V. Metaxa, N. Skourlis, C. Papanikolaou, A. Kalogeropoulou, E. Pitaraki, A. Laskaris, M. Hatzigeorgiou, A. Grekas, E. Kokkou, C. Vassiliadou, G. Dedousis, M. Toutouza-Giotsa, C. Tselika, S. Poulopouloou, M. Toutouza.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The ATTICA study is supported by research grants from the Hellenic Cardiology Society [HCS2002] and the Hellenic Atherosclerosis Society [HAS2003].