Vitamins: a nutritional intervention to modulate the Alzheimer’s disease progression

ABSTRACT

Background: Alzheimer’s disease is known as one of the fastest growing lethal diseases worldwide where we have limited and undesired ways for regulating its pathological progress. Now-a-days, nutritional compounds have been using to treat several brain disorders and one of them; vitamins were strongly reported to combat cognition and memory deterioration in neurodegenerative diseases including Alzheimer’s disease. Objective: Here, the author tried to find the precise physiological roles, status, and worth of vitamins in the brain and how exactly these nutrients modulate progression of Alzheimer’s disease. Results & Discussion: After a comprehensive and systematic literature review, the author reports that vitamins have various targets in Alzheimer’s disease pathogenesis by which they act to avert the neuronal dysfunction in the disease. Several Alzheimer’s disease-associated neurological deficits have reported regulating by vitamin intake but the beneficial effects identified mostly in combinatorial and long-term studies. Conclusion: In this way, the author suggests that it might be better to test vitamins with other components over single vitamin approach for a compatible and synergistic effect as well as using a combination of vitamin with other compounds can target multiple pathways. This strategy may help in deteriorating memory dysfunction and cognition impairment in Alzheimer’s disease pathophysiology.

KEYWORDS:

• Vitamins
• Alzheimer’s disease
• memory and cognition
• nutritional intervention
• antioxidants
• mild cognitive impairment
• animal studies
• clinical trials
• amyloid-tau proteins

Acknowledgement

The author is thankful to Shoolini University, Solan, H.P. INDIA for providing the library and internet facilities to carry out the literature regarding present work and thankful to Dr Lalit Sharma and Dr Varun Jiaswal for their kind suggestions and motivation for writing the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Notes on contributors

Jahangir Alam

Jahangir Alam is an "All India Council for Technical Education, AICTE" fellow of the GPAT (Graduate Pharmacy Aptitude Test) award. Currently, the author is a DST (Department of Science and Technology, Govt. of India) project fellow and working at a public research institution as research fellow. The author is interested in the field of supplementation, vitamins, dementia and Alzheimer’s disease.