ABSTRACT
Objective
Alzheimer’s disease is a progressive neurodegenerative disease and one of the most common causes of dementia. Despite recent advancements, there exists an unmet need for a suitable therapeutic option. This study aimed to evaluate the protective effects of the combination of resveratrol (20 mg/kg/day p.o.) and tannic acid (50 mg/kg/day p.o.) to reduce aluminium trichloride-induced Alzheimer’s disease in rats.
Methods
Wistar rats weighing 150–200g were administered with aluminium chloride (100 mg/kg/day p.o.) for 90 days to induce neurodegeneration and Alzheimer’s disease. Neurobehavioral changes were assessed using novel object recognition test, elevated plus maze test, and Morris water maze test. Histopathological studies were performed using H&E stain and Congo Red stains to check amyloid deposits. Further oxidative stress was measured in brain tissue.
Results
Aluminium trichloride treated negative control group showed cognitive impairment in the Morris water maze test, novel object recognition test, and elevated plus maze test. Further, the negative control group showed significant oxidative stress, increase amyloid deposits, and severe histological changes. Treatment with the combination of resveratrol and tannic acid showed significant attenuation in cognitive impairment. The oxidative stress markers and amyloid plaque levels were significantly attenuated with the treatment.
Conclusion
The present study indicates the beneficial effects of resveratrol-tannic acid combination in AlCl3 induced neurotoxicity in rats.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Data availability statement
The data that support the findings of this study are available on request from the corresponding author.
Additional information
Funding
Notes on contributors
Anisha Bhounsule
Anisha Bhounsule, M. Pharm is a post-graduate from Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy.
Lokesh Kumar Bhatt
Lokesh Kumar Bhatt, Ph. D. is an Associate Professor of Pharmacology at Department of Pharmacology, SVKM's Dr. Bhanuben Nanavati College of Pharmacy.