A novel 1,10-seco withanolide from Physalis peruviana

Abstract

A novel 1,10-seco withanolide, 1,10-seco withaperuvin C (1), together with four known withanolides, 4β-hydroxywithanolide E (2), visconolide (3), withanolide F (4), and withaphysanolide (5), was isolated from the aerial parts of Physalis peruviana. The structures of compounds 1–5 were determined on the basis of spectroscopic methods including extensive 1D and 2D NMR analysis. In addition, the possible biogenetic relationships among these five withanolides are discussed.

Keywords:

• Physalis peruviana
• 1,10-seco withaperuvin C
• withanolide
• steroid

Acknowledgements

The authors are grateful to the members of the analytical group for the spectral measurements in the Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences.