Synthesis and MDR inhibitory activity evaluation of derivatives of schizandrin A

Abstract

Eighteen schizandrin A derivatives, possessing an acyl group at 7-OH and/or halogen(s) at C-4 and C-11, were designed and synthesized for evaluation of their in vitro ability to inhibit multidrug resistance (MDR). They exhibit weak ability to restore the intracellular Rhodamine 123 in human hepatocarcinoma MDR cell lines Bel7402 and HCT8 relative to the reference drug verapamil.

Keywords:

• schizandrin A
• lignans
• multidrug resistance inhibitory activity

Acknowledgement

We are grateful to the National Natural Science Foundation of China (No. 30630069) for financial support of this research.