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Cameroonemide A: a new ceramide from Helichrysum cameroonense

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Pages 629-633 | Received 31 Jan 2010, Accepted 12 Apr 2010, Published online: 13 Jul 2010
 

Abstract

From the extracts of all parts of the plant Helichrysum cameroonense, five compounds were isolated and identified. One of them, a ceramide, named cameroonemide A (1), is reported for the first time as a new natural product. Its structure was determined by comprehensive analyses of their 1D and 2D NMR and HR-EI-MS spectral data. The remaining four known compounds were identified by comparing their spectroscopic data with those reported in the literature as kaurenoic acid (2), 3-acetyloxykaurenoic acid (3), β-sitosterol (4), and β-sitosterol glucopyranoside (5). Preliminary studies showed that 3-acetyloxykaurenoic acid (3) inhibited the alga Chlorella fusca, while kaurenoic acid (2) showed strong antibacterial activity against Bacillus megaterium.

Acknowledgement

The authors are grateful to the Alexander von Humboldt (AvH) Foundation for the fellowship awarded to S.F.K at the University of Paderborn, Germany.

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