Chemical constituents of the stem bark of Morus cathayana

Abstract

Phytochemical investigation of the stem bark of Morus cathayana led to the isolation and identification of six new compounds, cathayanons F–J (1–5) and cathayanin A (6), and two known compounds, cathayanins B–C (7–8). Their structures were elucidated by spectroscopic methods. Compounds 1, 2, 3, 5, and 7 exhibited weak activities against five human cancer cell lines, with IC₅₀ values ranging from 4.7 to 9.8 μg/ml.

Keywords:

• Morus cathayana
• flavonoids
• cytotoxic activities

Acknowledgements

This research was supported by the National Natural Science Foundation of China (No. 20432030), the Basic Scientific Research Foundation of the Central Government of China (No. 2006QN04), and the Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education.