Dibenzocyclooctadiene lignans from the fruits of Schisandra wilsoniana and their anti-HIV-1 activities

Abstract

Three new dibenzocyclooctadiene lignans, wilsonilignans A–C (1–3), together with nine known ones, were isolated from the fruits of Schisandra wilsoniana. The structures of 1–3 were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. Compounds 1–3 were also evaluated for their anti-HIV-1 activities and showed bioactivity with EC₅₀ values of 3.26, 6.18, and 2.87 μg/ml, respectively.

Keywords:

• Schisandra wilsoniana
• fruits
• dibenzocyclooctadiene lignans
• anti-HIV-1 activity

Acknowledgements

This project was supported financially by the NSFC (Nos 30830115 and 20802082), funds from the Chinese Academy of Sciences (‘Xibuzhiguang’ to W.-L.X. and No. KSCX1-YW-R-24), 973 programs (Nos 2009CB522300 and 2009CB940900), and the Young Academic and Technical Leader Rising Foundation of Yunnan Province (2006PY01-47).