Anti-inflammatory flavonolignans from Hydnocarpus anthelminthica seeds

Abstract

A new flavonolignan, anthelminthicol A (1), together with four known compounds, was isolated from the EtOAc extracts of the seeds of Hydnocarpus anthelminthica. Their structures were elucidated using extensive spectroscopic techniques. Bioassay showed that compounds 3–5 could inhibit nitric oxide production in LPS-stimulated RAW 264.7 macrophage cell lines, with IC₅₀ values of 7.81, 9.38, and 10.55 μM, respectively.

Keywords:

• Hydnocarpus anthelminthica
• Flacourtiaceae
• flavonolignan
• anthelminthicol A
• nitric oxide (NO) production

Acknowledgements

This work was financially supported by the following grants: ‘Xi-Bu-Zhi-Guang’ Project from Chinese Academy of Sciences; ‘Talent Scholarship of Yunnan Youth (No. 2007PY01-48)’; and Key Project for Drug Innovation (2008ZX09401-004) from the Ministry of Science and Technology of China.

Notes

^†These authors contributed equally to this work.